Gene content    
ABI2 ( by HUGO)
Abl-Interactor
Tumor suppressor gene
Abl-Interactor 2
Abelson Interactor 2
Arg-Binding Protein 1
AblBP3
ABI-2
ABI2B
AIP-1
SSH3BP2
Abl Binding Protein 3
Abl Interactor 2
Abl-Interacting Protein 1 (SH3-Containing Protein)
Abl-Interactor Protein 2b
Arg Protein Tyrosine Kinase-Binding Protein
argBP1
argBPIA
argBPIB
ARGBPIA
Abi-2
ArgBP1
Abl-Binding Protein 3
NCBI: 2q33    Ensembl: 2q33.2
ABI2_HUMANSize: 513 amino acidsMass: 55663 Da

  • Subunit: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for ABI2: 2ED0 (3D) [IMAGE] 3P8C (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: ABI2_HUMAN, Q9NYB9 Function: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA Gene Ontology (GO): Selected molecular function terms (see all 10): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding TAS 7590236 GO:0005515 protein binding IPI 17101133 GO:0008093 cytoskeletal adaptor activity TAS 12011975 GO:0017124 SH3 domain binding TAS 8649853 GO:0019900 kinase binding NAS 8649853 [IMAGE] Find genes that share ontologies with ABI2 About GenesLikeMe Phenotypes:
  • Similarity:
    Belongs to the ABI family
                          
    Contains 1 SH3 domain
                          
    Contains 1 t-SNARE coiled-coil homology domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000727T_SNARE_domTarget SNARE coiled-coil regionDomain
    IPR001452SH3_domainSH3Domain
    IPR012849Abl-interactor_HHR_domAbl-interactor HHRFamily
    BlocksIPB001452SH3 domain signatureSH3 domain signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process actin polymerization or depolymerization NAS GOA 11516653
    cell migration TAS GOA 12011975
    cellular component movement IDA GOA 11516653
    cytoskeleton organization TAS GOA 12011975
    peptidyl-tyrosine phosphorylation IDA GOA 17101133
    Cellular Component cytoplasm TAS GOA 8649853
    cytosol IDA GOA 17101133
    filopodium IDA GOA 11516653
    lamellipodium IDA GOA 11516653
    Molecular Function cytoskeletal adaptor activity TAS GOA 12011975
    DNA binding TAS GOA 7590236
    kinase binding NAS GOA 8649853
    proline-rich region binding IPI GOA 7590236
    protein binding IPI GOA 17101133
    SH3 domain binding TAS GOA 8649853
    SH3 domain binding IPI GOA 7590236
    ubiquitin protein ligase binding IPI GOA 18632609

    ABI2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene