Gene content  |
|
|---|---|
| ABL1 (-- by HUGO) | |
| C-Abl Oncogene 1, Non-Receptor Tyrosine Kinase | |
| -- & Oncogene | |
| NCBI: 9q34.1 Ensembl: 9q34.12 | |
|
NONE | |
| Protein Domain/Family |
||||
|---|---|---|---|---|
| Source | ID | Domain | Name | Type |
| InterPro | IPR000719 | Prot_kinase_dom | Protein kinase | Domain |
| IPR000980 | SH2 | SH2 motif | Domain | |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom | Tyrosine protein kinase | Domain | |
| IPR001452 | SH3_domain | SH3 | Domain | |
| IPR008266 | Tyr_kinase_AS | Tyrosine protein kinase, active site | Active Sites | |
| IPR011009 | Kinase-like_dom | Protein kinase-like | Domain | |
| Blocks | IPB000980 | SH2 domain signature | SH2 domain signature | |
| IPB001452 | SH3 domain signature | SH3 domain signature | ||
| IPB008266 | Tyrosine protein kinase | Tyrosine protein kinase, active site | ||
| Gene Ontology |
||||
|---|---|---|---|---|
| Type | Term | Evidence | Source | Pub |
| Biological Process | ATP binding | IEA | GOA | |
| cellular component unknown | ND | GOA | ||
| DNA binding | NAS | GOA | PubMed | |
| DNA damage response, signal transduction resulting in induction of apoptosis | TAS | GOA | PubMed | |
| molecular function unknown | ND | GOA | ||
| nucleus | NAS | GOA | PubMed | |
| protein binding | IPI | GOA | PubMed | |
| protein-tyrosine kinase activity | TAS | GOA | PubMed | |
| S-phase-specific transcription in mitotic cell cycle | TAS | GOA | PubMed | |
| transferase activity | IEA | GOA | ||
| Cellular Component | nucleotide binding | IEA | GOA | |
| Molecular Function | intracellular signaling cascade | IEA | GOA | |
| mismatch repair | TAS | GOA | PubMed | |
| protein amino acid phosphorylation | IEA | GOA | ||
| regulation of progression through cell cycle | TAS | GOA | PubMed | |
| regulation of transcription, DNA-dependent | TAS | GOA | PubMed | |
| Disorder & Mutation |
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|---|---|---|---|---|
| Source | Disease | |||
| SWISS-PROT | Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B lymphoid, and sometimes T lymphoid cells, but not marrow fibroblasts. Note=The gene represented in this entry is involved in disease pathogenesis | |||
| SWISS-PROT | Note=A chromosomal aberration involving ABL1 has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) | |||
| ABL1 cross reference |
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