Gene content  |
| ACCN1 (approved by HUGO) |
| amiloride-sensitive cation channel 1, neuronal |
| Tumor suppressor gene |
| amiloride-sensitivecationchannelneuronal1Acid-sensingionchannel22MDEG1Brainsodiumchannel12BNC11Amiloride-sensitivebrainsodiumchannel2BNaC11Mammaliandegenerinhomolog2ASIC21ACCN2hBNaC11degenerin2ASIC2a1neuronalamiloride-sensitivecationchannel12Amiloride-sensitivecationchannelneuronal12 |
| NCBI: 17q12 Ensembl: 17q12 |
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Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes (By similarity) Miscellaneous: Inhibited by anti-inflammatory drugs like salicylic acid (By simila
Subunit: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM (By similarity). Interacts with PRKCABP and ACCN3
Tissue specificity: Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary Primers: "" Origene genome-wide validated SYBR primer pairs: ACCN1 "" SABiosciences RT2 qPCR Primer Assay for ACCN1: PPH01364A
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate
Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN1 subfamily
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