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Tissue specificity: Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle [IMAGE] Custom PCR Arrays for ADAMTS9 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for
Function: Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos
Catalytic activity: Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu- -Ala-1429 site Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004175 endopeptidase activity -- -- GO:0004222 metalloendopeptidase activity IEA -- GO:0008237 metallopeptidase activity IDA 12514189 GO:0008270 zinc ion binding IEA -- [IMAGE] Find genes that share ontologies with ADAMTS9 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for ADAMTS9: Decreased cilium length after 6 MGI mutant phenotypes (inferred from 1 allele[IMAGE]) (MGI details for Adamts9): embryogenesis integument limbs/digits/tail mortality/aging nervous system pigmentation [IMAGE] Find genes that share phenotypes with ADAMTS9 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTS9 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAMTS9 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTS9 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAMTS9 miRNA Products: miRTarBase miRNAs that target ADAMTS9: hsa-mir-29a-3p (MIRT005668) [IMAGE] Block miRNA regulation of human, mouse, rat ADAMTS9 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate ADAMTS9 (see all 53): hsa-miR-548j hsa-miR-4254 hsa-miR-607 hsa-miR-29a hsa-miR-25 hsa-miR-30d hsa-miR-877* hsa-miR-9 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS9 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for ADAMTS9 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat ADAMTS9 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for ADAMTS9 Clone Products: [IMAGE] OriGene clones in human, mouse for ADAMTS9 (see all 5) OriGene ORF clones in mouse, rat for ADAMTS9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: ADAMTS9 (NM_182920) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS9 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS9 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for ADAMTS9 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for ADAMTS9 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS9
Similarity: Contains 1 disintegrin domain Contains 1 GON domain Contains 1 peptidase M12B domain Contains 15 TSP type-1 domains [IMAGE]
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