|
Subunit: Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform. Component of the AIM2 inflammasome. Interacts with PYCARD, IFI16, EIF2AK2/PKR and MAPRE1 Miscellaneous: Defects in AIM2 may be a cause of microsatellite unstable colon cancers Sequence caution: Sequence=AAH10940.1; Type=Frameshift; Positions=340;
Tissue specificity: Expressed in spleen, small intestine, peripheral blood leukocytes, and testis [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including AIM2: Antiviral Response in human mouse rat Inflammasomes in human mouse rat Primer Products: [IMAGE] OriGene
Function: UniProtKB/Swiss-Prot Summary: AIM2_HUMAN, O14862 Function: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity Enzyme regulation: In absence of dsDNA DAPIN and HIN-20 domain can interact inducing a closed conformation; an autoinhibitory mechanism is proposed in which binding to dsDNA liberates the DAPIN domain for homotypic downstream signaling interactions with PYCARD
Similarity: Belongs to the HIN-200 family Contains 1 DAPIN domain Contains 1 HIN-200 domain [IMAGE]
|
