Gene content
Symbol	AKAP12 ( by HUGO)
Name	A Kinase (PRKA) Anchor Protein 12
Category	Tumor suppressor gene
Alias	A Kinase (PRKA) Anchor Protein 12 Src-Suppressed C Kinase Substrate AKAP250 AKAP 250 A Kinase (PRKA) Anchor Protein (Gravin) 12 gravin SSeCKS A-Kinase Anchor Protein 12 A-Kinase Anchor Protein 250kDa Kinase Scaffold Protein Gravin Myasthenia Gravis Autoantigen Gravin AKAP-12 Gravin A-Kinase Anchor Protein 250 KDa Myasthenia Gravis Autoantigen
Cytogenetic band	NCBI: 6q24-q25    Ensembl: 6q25.1
Protein information	AKA12_HUMAN Size: 1782 amino acids Mass: 191482 Da Subunit: Binds to dimeric RII-alpha regulatory subunit of PKC Miscellaneous: Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG) Sequence caution: Sequence=BAE06085.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Tissue specificity: Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells [IMAGE] Custom PCR Arrays for AKAP12 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in huma Function: UniProtKB/Swiss-Prot Summary: AKA12_HUMAN, Q02952 Function: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC) Similarity: Contains 3 AKAP domains [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001573	Pkinase-A_anch_WSK-motif	Protein kinase A anchoring region	Domain
Blocks	IPB001573	Protein kinase A anchoring domain	Protein kinase A anchoring domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	G-protein coupled receptor signaling pathway	TAS	GOA	10858453
	positive regulation of cAMP biosynthetic process	IMP	GOA	17081159
	positive regulation of protein kinase A signaling	IMP	GOA	17081159
Molecular Function	adenylate cyclase binding	IPI	GOA	17081159

AKAP12 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene