|
Subunit: Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA. Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2 Sequence caution: Sequence=AAC50065.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC50065.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAD21311.1; Type=Frameshift; Positions=2614, 2647; Sequence=AAD40799.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD40799.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAL40923.1; Type=Frameshift; Positions=2614, 2647; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for AKAP13: 2DRN (3D) [IMAGE] 2LG1 (3D) [IMAGE]
Tissue specificity: Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb tran
Function: UniProtKB/Swiss-Prot Summary: AKP13_HUMAN, Q12802 Function: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions
Similarity: Contains 1 DH (DBL-homology) domain Contains 1 PH domain Contains 1 phorbol-ester/DAG-type zinc finger [IMAGE]
|
