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Subunit: Homotetramer (By similarity)
Function: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity)
Catalytic activity: Retinal + NAD(+) + H(2)O = retinoate + NADH Enzyme Numbers (IUBMB): EC 1.2.1.361 2 EC 1.2.12 Gene Ontology (GO): 5 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0001758 retinal dehydrogenase activity ISS -- GO:0004028 3-chloroallyl aldehyde dehydrogenase activity ISS -- GO:0016491 oxidoreductase activity -- -- GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- GO:0016918 retinal binding ISS -- [IMAGE] Find genes that share ontologies with ALDH1A2 About GenesLikeMe Phenotypes: Selected MGI mutant phenotypes (inferred from 6 alleles[IMAGE]) (MGI details for Aldh1a2) (see all 19): cardiovascular system cellular craniofacial embryogenesis endocrine/exocrine gland growth/size/body hearing/vestibular/ear hematopoietic system homeostasis/metabolism immune system limbs/digits/tail mortality/aging muscle nervous system normal [IMAGE] Find genes that share phenotypes with ALDH1A2 About GenesLikeMe Animal Models: MGI mouse knock-outs for ALDH1A2: Aldh1a2tm1Ipc Aldh1a2tm1Soc Aldh1a2tm1Gdu [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH1A2 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALDH1A2 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALDH1A2 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALDH1A2 miRNA Products: miRTarBase miRNAs that target ALDH1A2: hsa-mir-193b-3p (MIRT041305), hsa-mir-10a-5p (MIRT047601), hsa-mir-615-3p (MIRT039966), hsa-mir-155-5p (MIRT020672) [IMAGE] Block miRNA regulation of human, mouse, rat ALDH1A2 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate ALDH1A2 (see all 31): hsa-miR-2052 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-137 hsa-miR-449c* hsa-miR-340 hsa-miR-4267 hsa-miR-23a [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: ALDH1A2 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for ALDH1A2 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat ALDH1A2 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for ALDH1A2 Clone Products: [IMAGE] OriGene clones in human, mouse for ALDH1A2 (see all 18) OriGene ORF clones in mouse, rat for ALDH1A2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 3): ALDH1A2 (NM_003888) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH1A2 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH1A2 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for ALDH1A2 [IMAGE] ESI BIO PureStem Progenitor for ALDH1A2: [IMAGE] PureStem MEL2, NCr-fac Progenitor In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1A2 Flow Cytometry Products: [IMAGE] eBioscience FlowRNA Probe Sets (VA1-13523) for ALDH1A2 [IMAGE]
Similarity: Belongs to the aldehyde dehydrogenase family [IMAGE]
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