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Subunit: Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1 Sequence caution: Sequence=BAD97000.1; Type=Erroneous initiation; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for ANP32A: 2JE0 (3D) [IMAGE] 2JE1 (3D) [IMAGE]
Tissue specificity: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus cal
Function: UniProtKB/Swiss-Prot Summary: AN32A_HUMAN, P39687 Function: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 16169070 GO:0044822 poly(A) RNA binding IDA -- [IMAGE] Find genes that share ontologies with ANP32A About GenesLikeMe Phenotypes:
Similarity: Belongs to the ANP32 family Contains 4 LRR (leucine-rich) repeats Contains 1 LRRCT domain [IMAGE]
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