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Subunit: Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2 Developmental stage: Expressed in fetal brain Sequence caution: Sequence=AAD28183.1; Type=Frameshift; Positions=1322, 1338; Sequence=AAF01784.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=CAA10317.1; Type=Erroneous initiation; Sequence=CAB61207.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Tissue specificity: Widely expressed (at protein level). Specifically expressed in the CNS [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including APC2: Ubiquitin Ligases in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse f
Function: UniProtKB/Swiss-Prot Summary: APC2_HUMAN, O95996 Function: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005488 binding -- -- GO:0005515 protein binding IPI 10644998 GO:0008013 beta-catenin binding IDA 9823329 GO:0008017 microtubule binding IEA -- [IMAGE] Find genes that share ontologies with APC2 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for APC2: Increased cell number in G2M, Increased gamma-H2AX phosphory
Similarity: Belongs to the adenomatous polyposis coli (APC) family Contains 6 ARM repeats [IMAGE]
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