Gene content    
ARHGAP29 ( by HUGO)
Rho GTPase Activating Protein
Tumor suppressor gene
Rho GTPase Activating Protein 29
PARG1
Rho-Type GTPase-Activating Protein 29
PTPL1-Associated RhoGAP Protein 1
PTPL1-Associated RhoGAP 1 (PARG1)
Rho GTPase-Activating Protein 29
NCBI: 1p22.1    Ensembl: 1p21.3
RHG29_HUMANSize: 1261 amino acidsMass: 142064 Da

  • Subunit: Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain. Interacts with RASIP1 (By similarity) Sequence caution: Sequence=AAH67839.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
  • Tissue specificity: Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney [IMAGE] Custom PCR Arrays for ARHGAP29 Primer Products: [IMAGE] OriGene qPCR prime
  • Function:
    UniProtKB/Swiss-Prot Summary: RHG29_HUMAN, Q52LW3 Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis
  • Similarity:
    Contains 1 phorbol-ester/DAG-type zinc finger
                          
    Contains 1 Rho-GAP domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000198RhoGAP_domRhoGAPDomain
    IPR002219Prot_Kinase_C-like_PE/DAG-bdProtein kinase C, phorbol ester/diacylglycerol bindingDomain
    IPR008936Rho_GTPase_activation_protRho GTPase activation proteinDomain
    BlocksIPB000198RhoGAP domainRhoGAP domain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of Rho GTPase activity TAS GOA 9305890
    Rho protein signal transduction TAS GOA 9305890
    Molecular Function Rho GTPase activator activity TAS GOA 9305890

    ARHGAP29 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene