Gene content
Symbol	ARL11 ( by HUGO)
Name	ADP-Ribosylation Factor-Like 11
Category	Tumor suppressor gene
Alias	ADP-Ribosylation Factor-Like 11 ARLTS1 ADP-Ribosylation Factor-Like Tumor Suppressor Protein 1 ADP-Ribosylation Factor-Like Protein 11
Cytogenetic band	NCBI: 13q14.2    Ensembl: 13q14.2
Protein information	ARL11_HUMAN Size: 196 amino acids Mass: 21391 Da Tissue specificity: Expressed in lung and leukocytes [IMAGE] Custom PCR Arrays for ARL11 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for ARL11 OriGene qSTAR qPCR primer pairs in human, mouse for ARL11 [IMAGE] Pre-validated RT2 qPCR Primer Assay Function: UniProtKB/Swiss-Prot Summary: ARL11_HUMAN, Q969Q4 Function: May play a role in apoptosis. May act as a tumor suppressor Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 16189514 GO:0005525 GTP binding IEA -- [IMAGE] Find genes that share ontologies with ARL11 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for ARL11: Increased G2M DNA content Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL11 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARL11 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL11 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARL11 miRNA Products: [IMAGE] Block miRNA regulation of human, mouse, rat ARL11 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate ARL11 (see all 9): hsa-miR-3163 hsa-miR-3678-3p hsa-miR-4311 hsa-miR-513c hsa-miR-2115 hsa-miR-3622b-3p hsa-miR-1252 hsa-miR-514b-5p [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: ARL11 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for ARL11 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat ARL11 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for ARL11 Clone Products: [IMAGE] OriGene clones in human, mouse for ARL11 (see all 6) OriGene ORF clones in mouse, rat for ARL11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: ARL11 (NM_138450) [IMAGE] Sino Biological Human cDNA Clone for ARL11 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL11 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL11 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for ARL11 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for ARL11 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL11 Similarity: Belongs to the small GTPase superfamily. Arf family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR005225	Small_GTP-bd_dom	Small GTP-binding protein domain	Domain
	IPR006689	Small_GTPase_ARF/SAR	ARF/SAR superfamily	Family
Blocks	IPB006688	ADP-ribosylation factor	ADP-ribosylation factor

Gene Ontology
Type	Term	Evidence	Source	Pub
Molecular Function	protein binding	IPI	GOA	16189514

Disorder & Mutation
Source	Disease
SWISS-PROT	Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

ARL11 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene