Gene content
Symbol	ASCL1 ( by HUGO)
Name	Achaete-Scute Family BHLH Transcription Factor 1
Category	Other
Alias	Achaete-Scute Family BHLH Transcription Factor 1 ASH1 Class A Basic Helix-Loop-Helix Protein 46 ASH-1 HASH1 bHLHa46 Achaete-Scute Complex (Drosophila) Homolog-Like 1 Achaete-Scute Complex Homolog 1 (Drosophila) Achaete-Scute Complex-Like 1 (Drosophila) MASH1 Achaete Scute Protein Achaete-Scute Complex Homolog 1 Achaete-Scute Complex-Like 1 Achaete-Scute Homolog 1 BHLHA46 hASH1
Cytogenetic band	NCBI: 12q23.2    Ensembl: 12q23.2
Protein information	ASCL1_HUMAN Size: 236 amino acids Mass: 25454 Da Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 Function: UniProtKB/Swiss-Prot Summary: ASCL1_HUMAN, P50553 Function: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3') Similarity: Contains 1 bHLH (basic helix-loop-helix) domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR011598	bHLH_dom	Helix-loop-helix DNA-binding	Domain
Blocks	IPB001092	Basic helix-loop-helix dimerization domain bHLH	Basic helix-loop-helix dimerization domain bHLH

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cerebral cortex GABAergic interneuron differentiation	IEP	GOA	12050665
	lung epithelial cell differentiation	NAS	GOA	12858003
	negative regulation of apoptotic process	IMP	GOA	17507989
	negative regulation of neuron differentiation	IDA	GOA	12000752
	negative regulation of transcription, DNA-templated	IDA	GOA	11736660
	neurogenesis	IDA	GOA	19008346
	noradrenergic neuron fate commitment	IMP	GOA	14532329
	Notch signaling pathway	IDA	GOA	16160079
	positive regulation of transcription from RNA polymerase II promoter	IDA	GOA	10903890
	response to retinoic acid	IEP	GOA	12000752
	sympathetic nervous system development	NAS	GOA	10903890
Cellular Component	nucleus	IDA	GOA	12858003
Molecular Function	bHLH transcription factor binding	IPI	GOA	10903890
	E-box binding	IDA	GOA	10903890
	protein binding	IPI	GOA	10903890
	sequence-specific DNA binding transcription factor activity	IDA	GOA	10903890

ASCL1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene