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Subunit: Heterodimer of BACH2 and Maf-related transcription factors (By similarity). Homodimer; disulfide-linked Sequence caution: Sequence=BAD92126.1; Type=Erroneous initiation; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for BACH2: 3OHU (3D) [IMAGE] 3OHV (3D) [IMAGE]
Tissue specificity: B-cell specific [IMAGE] Custom PCR Arrays for BACH2 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for BACH2 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BACH2 [IMAGE] QuantiTect SYBR Green Assays in human, m
Function: UniProtKB/Swiss-Prot Summary: BACH2_HUMAN, Q9BYV9 Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding -- -- GO:0003700 sequence-specific DNA binding transcription factor activity IEA -- GO:0005515 protein binding -- -- GO:0043565 sequence-specific DNA binding IEA -- [IMAGE] Find genes that share ontologies with BACH2 About GenesLikeMe Phenotypes: 3 GenomeRNAi human phenotypes for BACH2: Decreased influenza A/WSN/33 r Increased gamma-H2AX phosphory Synthetic lethal with Ras
Similarity: Belongs to the bZIP family. CNC subfamily Contains 1 BTB (POZ) domain Contains 1 bZIP (basic-leucine zipper) domain [IMAGE]
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