TAG for BAI3

Gene content

Symbol

BAI3 ( by HUGO)

Name

Brain-Specific Angiogenesis Inhibitor 3

Category

Tumor suppressor gene

Alias

Brain-Specific Angiogenesis Inhibitor 3
DJ91B17.1 (Brain-Specific Angiogenesis Inhibitor 3)
KIAA0550

Cytogenetic band

NCBI: 6q12 Ensembl: 6q12

Protein information

BAI3_HUMAN

Size: 1522 amino acids

Mass: 171518 Da

Subunit: Interacts with C1QL1, C1QL2, C1QL3 and C1QL4 Sequence caution: Sequence=BAA25476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for BAI3: 4DLO (3D) [IMAGE]

Tissue specificity: Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including BAI3: G Protein Coupled Receptors 384HT in human mouse rat Primer Produc

Function:

UniProtKB/Swiss-Prot Summary: BAI3_HUMAN, O60242 Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma

Similarity:

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily

Contains 1 CUB domain

Contains 1 GPS domain

Contains 4 TSP type-1 domains [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000203	GPS	GPS	Domain
	IPR000832	GPCR_2_secretin-like	GPCR, family 2, secretin-like	Family
	IPR000859	CUB_dom	CUB	Domain
	IPR000884	Thrombospondin_1_rpt	Thrombospondin, type I	Repeat
	IPR001879	GPCR_2_extracellular_dom	Hormone receptor, extracellular	Domain
	IPR008077	GPCR_2_brain-spec_angio_inhib	Brain-specific angiogenesis inhibitor	Family
Blocks	IPB000203	GPS domain	GPS domain
	IPB000832	G-protein coupled receptors family 2 (secretin-like)	G-protein coupled receptors family 2 (secretin-like)
	IPB000832	G-protein coupled receptors family 2 (secretin-like) IPB000859 CUB domain IPB008085 Thrombospondin type 1 repeat signature	G-protein coupled receptors family 2 (secretin-like)
	IPB000832	G-protein coupled receptors family 2 (secretin-like)	G-protein coupled receptors family 2 (secretin-like)
	IPB000832	G-protein coupled receptors family 2 (secretin-like)	G-protein coupled receptors family 2 (secretin-like)
	IPB000884	Thrombospondin	Thrombospondin, type I
	IPB008077	Brain-specific angiogenesis inhibitor precursor signature	Brain-specific angiogenesis inhibitor precursor signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	G-protein coupled receptor signaling pathway	TAS	GOA	15203201

BAI3 cross reference