Gene content    
BAMBI ( by HUGO)
BMP And Activin Membrane-Bound Inhibitor
Other
BMP And Activin Membrane-Bound Inhibitor
NMA
Non-Metastatic Gene A Protein
Putative Transmembrane Protein NMA
BMP And Activin Membrane-Bound Inhibitor Homolog (Xenopus Laevis)
BMP And Activin Membrane-Bound Inhibitor Homolog
NCBI: 10p12.3-p11.2    Ensembl: 10p12.1
BAMBI_HUMANSize: 260 amino acidsMass: 29108 Da

  • Tissue specificity: High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested [IMAGE] Pathway & Disease-focused RT2 Prof
  • Function:
    UniProtKB/Swiss-Prot Summary: BAMBI_HUMAN, Q13145 Function: Negatively regulates TGF-beta signaling Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004675 transmembrane receptor protein serine/threonine kinase activity -- -- GO:0005024 transforming growth factor beta-activated receptor activity -- -- GO:0005109 frizzled binding IPI 18838381 GO:0005114 type II transforming growth factor beta receptor binding TAS 18756595 [IMAGE] Find genes that share ontologies with BAMBI About GenesLikeMe Phenotypes:
  • Similarity:
    Belongs to the BAMBI family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR009345BMP/activin_membr-bound_inhibBMP and activin membrane-bound inhibitorFamily
    BlocksIPB009345BMP and activin membrane-bound inhibitorBMP and activin membrane-bound inhibitor

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell migration IDA GOA 19328798
    negative regulation of transforming growth factor beta receptor signaling pathway IMP GOA 19328798
    negative regulation of transforming growth factor beta receptor signaling pathway IDA GOA 14660579
    positive regulation of canonical Wnt signaling pathway IDA GOA 18838381
    positive regulation of catenin import into nucleus IMP GOA 18838381
    positive regulation of cell proliferation IMP GOA 18838381
    positive regulation of epithelial to mesenchymal transition IMP GOA 19328798
    positive regulation of protein binding IMP GOA 18838381
    positive regulation of transcription, DNA-templated IDA GOA 18838381
    regulation of cell shape IMP GOA 19328798
    Cellular Component cytoplasm IDA GOA 10942595
    plasma membrane IDA GOA 18756595
    Molecular Function frizzled binding IPI GOA 18838381
    type II transforming growth factor beta receptor binding TAS GOA 18756595

    BAMBI cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene