Gene content    
BCL10 ( by HUGO)
B-Cell CLL/Lymphoma 10
Tumor suppressor gene
B-Cell CLL/Lymphoma 10
CARD-Like Apoptotic Protein
CARD Containing Molecule Enhancing NF-KB
CARD-Containing Apoptotic Signaling Protein
CARD-Containing Proapoptotic Protein
Caspase-Recruiting Domain-Containing Protein
Cellular Homolog Of VCARMEN
Mammalian CARD-Containing Adapter Molecule E10
CIPER
CLAP
c-E10
cCARMEN
CARD-Containing Molecule Enhancing NF-Kappa-B
CED-3/ICH-1 Prodomain Homologous E10-Like Regulator
hCLAP
mE10
CARMEN
B-Cell Lymphoma/Leukemia 10
cellular-E10
Bcl-10
Cellular-E10
NCBI: 1p22    Ensembl: 1p22.3
BCL10_HUMANSize: 233 amino acidsMass: 26252 Da

  • Subunit: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity) 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for BCL10: 2MB9 (3D) [IMAGE]
  • Tissue specificity: Ubiquitous [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL10: NFKB Signaling Pathway in human mouse rat Apoptosis 384HT in human mouse rat Apoptosis in human mouse rat Antifungal Response in human mouse rat Antibacterial Response i
  • Function:
    UniProtKB/Swiss-Prot Summary: BCL10_HUMAN, O95999 Function: Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1
  • Similarity:
    Contains 1 CARD domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001315CARDCaspase RecruitmentDomain
    IPR011029DEATH-like_domDEATH-likeDomain
    BlocksIPB001315CARD interaction domainCARD interaction domain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process adaptive immune response TAS GOA 16831874
    cell death IDA GOA 10400625
    cellular response to mechanical stimulus IEP GOA 19593445
    innate immune response IEP GOA 16831874
    interleukin-6 biosynthetic process NAS GOA 16647297
    lymphotoxin A biosynthetic process NAS GOA 16647297
    negative regulation of mature B cell apoptotic process IDA GOA 15878976
    neural tube closure ISS GOA 11163238
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEP GOA 12761501
    positive regulation of interleukin-8 biosynthetic process IMP GOA 17095757
    positive regulation of mast cell cytokine production NAS GOA 16647297
    positive regulation of NF-kappaB transcription factor activity IDA GOA 10400625
    positive regulation of phosphorylation IDA GOA 15125833
    positive regulation of protein ubiquitination IDA GOA 14695475
    positive regulation of transcription, DNA-templated IDA GOA 15207693
    protein homooligomerization TAS GOA 16831874
    protein homooligomerization ISS GOA 16831874
    protein oligomerization IPI GOA 14695475
    response to food IDA GOA 17095757
    response to molecule of bacterial origin IEP GOA 16831874
    T cell receptor signaling pathway IDA GOA 15125833
    toll-like receptor signaling pathway IC GOA 16831874
    Cellular Component CBM complex NAS GOA 15125833
    colocalizes_with lipopolysaccharide receptor complex IDA GOA 16831874
    colocalizes_with T cell receptor complex IDA GOA 12154360
    cytoplasm IDA GOA 11021819
    cytosol IDA GOA 12154360
    lysosome IDA GOA 15082780
    nucleus IDA GOA 16280327
    perinuclear region of cytoplasm IDA GOA 16127295
    protein complex IDA GOA 14695475
    Molecular Function contributes_to kinase activator activity IDA GOA 15125833
    enzyme binding IPI GOA 14695475
    kinase binding IPI GOA 16831874
    NF-kappaB binding IDA GOA 16280327
    protease binding IPI GOA 18223652
    protein binding IPI GOA 1040062
    protein C-terminus binding IPI GOA 11053425
    protein kinase B binding IPI GOA 16280327
    protein kinase binding IDA GOA 17052756
    protein self-association IPI GOA 15125833
    transcription coactivator activity IDA GOA 15207693
    transcription factor binding IPI GOA 15207693
    ubiquitin binding IDA GOA 15082780
    ubiquitin protein ligase binding IPI GOA 16395405

    Disorder & Mutation    
    Source Disease
    GenatlasB cell/lymphoma 10,of mucosa associated lymphoid tissues (MALT lymphomas),affecting predominantly the gastric mucosa,low grade evolving to high grade form with translocation t(1;14)(p22;q32)
    SWISS-PROTNote=Defects in BCL10 are involved in various types of cancer
    SWISS-PROTMesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note=The gene represented in this entry may be involved in disease pathogenesis
    SWISS-PROTNote=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions

    BCL10 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene