Gene content    
BCL2L2 ( by HUGO)
BCL2-Like
Oncogene
BCL2-Like 2
BCLW
Apoptosis Regulator Bcl-W
Protein Phosphatase 1
Regulatory Subunit 51
BCL-W
BCL2-L-2
PPP1R51
Bcl-2-Like Protein 2
Protein Phosphatase 1
Regulatory Subunit 51
Bcl2-L-2
KIAA0271
NCBI: 14q11.2-q12    Ensembl: 14q11.2
B2CL2_HUMANSize: 193 amino acidsMass: 20746 Da

  • Subunit: Interacts with BOP (By similarity) Sequence caution: Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for BCL2L2: 1MK3 (3D) [IMAGE] 1O0L (3D) [IMAGE] 1ZY3 (3D) [IMAGE] 2Y6W (3D) [IMAGE]
  • Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or li
  • Function:
    UniProtKB/Swiss-Prot Summary: B2CL2_HUMAN, Q92843 Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX
  • Similarity:
    Belongs to the Bcl-2 family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002475Bcl2-likeBCL2-like apoptosis inhibitorFamily
    IPR003093Bcl2_BH4Apoptosis regulator Bcl-2 protein, BH4Domain
    BlocksIPB000712Apoptosis regulator Bcl-2 proteinApoptosis regulator Bcl-2 protein, BH

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of apoptotic process IMP GOA 17289999
    spermatogenesis TAS GOA 8761287
    Molecular Function protein binding IPI GOA 15694340

    BCL2L2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene