TAG for BCR

Gene content

Symbol

BCR ( by HUGO)

Name

Breakpoint Cluster Region

Category

Other

Alias

Breakpoint Cluster Region
BCR1
D22S11
Renal Carcinoma Antigen NY-REN-26
EC 2.7.11.1
ALL
CML
PHL
D22S662
BCR/FGFR1 Chimera Protein
Breakpoint Cluster Region Protein
FGFR1/BCR Chimera Protein

Cytogenetic band

NCBI: 22q11.23 Ensembl: 22q11.23

Protein information

BCR_HUMAN

Size: 1271 amino acids

Mass: 142819 Da

Subunit: Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK Sequence caution: Sequence=BAE06073.1; Type=Erroneous initiation; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for BCR: 1K1F (3D) [IMAGE] 2AIN (3D) [IMAGE]

Function:

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity

Catalytic activity:

ATP + a protein = ADP + a phosphoprotein

Similarity:

Contains 1 C2 domain

Contains 1 DH (DBL-homology) domain

Contains 1 PH domain

Contains 1 Rho-GAP domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000008	C2_dom	C2	Domain
	IPR000198	RhoGAP_dom	RhoGAP	Domain
	IPR000219	DH-domain	DH	Domain
	IPR001331	GDS_CDC24_CS	Guanine-nucleotide dissociation stimulator, CDC24	Domain
	IPR001849	Pleckstrin_homology	Pleckstrin-like	Domain
	IPR008936	Rho_GTPase_activation_prot	Rho GTPase activation protein	Domain
	IPR011993	PH_like_dom	Pleckstrin homology-type	Domain
Blocks	IPB000198	RhoGAP domain	RhoGAP domain
	IPB000219	DH domain	DH domain
	IPB001849	Pleckstrin-like	Pleckstrin-like

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	protein phosphorylation	TAS	GOA	1657398
Biological Process	signal transduction	TAS	GOA	1657398
Cellular Component	extracellular vesicular exosome	IDA	GOA	19056867
Cellular Component	membrane	IDA	GOA	19946888
Molecular Function	GTPase activator activity	TAS	GOA	1903516
Molecular Function	protein binding	IPI	GOA	10887132

Disorder & Mutation
Source	Disease
SWISS-PROT	Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B lymphoid, and sometimes T lymphoid cells, but not marrow fibroblasts. Note=The gene represented in this entry is involved in disease pathogenesis
SWISS-PROT	Note=A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)

BCR cross reference