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| BLM_HUMAN | Size: 1417 amino acids | Mass: 159000 Da |
Subunit: Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ubiquitinated FANCD2. Interacts with RMI complex. Interacts directly with RMI1 (via N-terminus region) component of RMI complex. Interacts with SUPV3L1. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with TOP3A (via N-terminus region). Interacts with SPIDR (via C-terminus region); the interaction is direct and required to target BLM to sites of DNA damage 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for BLM: 2KV2 (3D) [IMAGE] 2RRD (3D) [IMAGE] 3WE2 (3D) [IMAGE] 3WE3 (3D) [IMAGE] 4CDG (3D) [IMAGE] 4CGZ (3D) [IMAGE]
Function: Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE) Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE)
Catalytic activity: ATP + H(2)O = ADP + phosphate
Similarity: Belongs to the helicase family. RecQ subfamily Contains 1 helicase ATP-binding domain Contains 1 helicase C-terminal domain Contains 1 HRDC domain [IMAGE]
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