Gene content  |
| BNIP3L ( by HUGO) |
| BCL2/Adenovirus E1B 19kDa Interacting Protein 3-Like |
| Tumor suppressor gene |
| BCL2/Adenovirus E1B 19kDa Interacting Protein 3-Like NIX Adenovirus E1B19K-Binding Protein B5 NIP3L BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 3A NIP3-Like Protein X BCL2/Adenovirus E1B 19kD-Interacting Protein 3-Like BNIP3a BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 3-Like BCL2/Adenovirus E1B 19-Kd Protein-Interacting Protein 3a BNIP3A BNIP3H |
| NCBI: 8p21 Ensembl: 8p21.2 |
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Subunit: Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains) Sequence caution: Sequence=CAI46217.1; Type=Erroneous termination; Positions=122; Note=Translated as Glu;
Function: UniProtKB/Swiss-Prot Summary: BNI3L_HUMAN, O60238 Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor
Similarity: Belongs to the NIP3 family [IMAGE]
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