Gene content
Symbol	BTG2 ( by HUGO)
Name	BTG Family, Member
Category	Tumor suppressor gene
Alias	BTG Family Member 2 NGF-Inducible Anti-Proliferative Protein PC3 PC3 B-Cell Translocation Gene 2 Nerve Growth Factor-Inducible Anti-Proliferative Pheochromacytoma Cell-3 TIS21 Protein BTG2 BTG Family Member 2
Cytogenetic band	NCBI: 1q32    Ensembl: 1q32.1
Protein information	BTG2_HUMAN Size: 158 amino acids Mass: 17416 Da Subunit: Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for BTG2: 3DJU (3D) [IMAGE] 3E9V (3D) [IMAGE] Function: UniProtKB/Swiss-Prot Summary: BTG2_HUMAN, P78543 Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth Similarity: Belongs to the BTG family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR002087	Anti_prolifrtn	Anti-proliferative protein	Family
Blocks	IPB002087	Anti-proliferative protein	Anti-proliferative protein

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cellular response to DNA damage stimulus	IDA	GOA	8944033
	DNA repair	TAS	GOA	8944033
	neuron projection development	IMP	GOA	18773938
	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA	GOA	18337750
Cellular Component	extracellular vesicular exosome	IDA	GOA	19056867
Molecular Function	protein binding	IPI	GOA	11136725

BTG2 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene