Gene content |
| C13ORF15 (approved by HUGO) |
| chromosome 13 open reading frame 15 |
| Other & Tumor suppressor gene |
| chromosome13openreadingframe151KIAA05642RGC-321responsegenetocomplement32protein2bA157L14.21MGC873382RGC321 |
| NCBI: 13q14.11 Ensembl: 13q14.11 |
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Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase Secondary accessions: Q6NZ48 Q9UL69 Alternative splic
Subunit: Interacts with CDK1 and PLK1
Tissue specificity: Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells Primers: "" Origene genome-wide validated SY
Function: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition
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