Gene content  |
| C17ORF37 (approved by HUGO) |
| chromosome 17 open reading frame 37 |
| Oncogene |
| chromosome17openreadingframe371HBVX-transactivatedgeneprotein2XTP41RDX122MGC148321C352ORB31proteinC17orf372HBVXAg-transactivatedprotein42Protein |
| NCBI: 17q12 Ensembl: 17q12 |
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Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor; Cytoplasmic side (Probable). Note=Concentrates at the leading edge of migrating cells
Tissue specificity: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein le
Function: May be involved in a redox-related process (Potential). May act as a signaling protein that increases migratory potential and invasiveness of cancer cells by enhancing NF-kappa-B activation mediated by AKT1, hence the transcription of downstream genes such as MMP9, VEGF and PLAU
Similarity: Belongs to the SelWTH family
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