Gene content    
CBFB ( by HUGO)
Core-Binding Factor, Beta Subunit
Other
Core-Binding Factor
Beta Subunit
Polyomavirus Enhancer-Binding Protein 2 Beta Subunit
CBF-beta
PEA2-beta
PEBP2-beta
SL3-3 Enhancer Factor 1 Subunit Beta
SL3/AKV Core-Binding Factor Beta Subunit
PEBP2B
Core-Binding Factor Subunit Beta
Polyomavirus Enhancer Binding Protein 2
Beta Subunit
SL3-3 Enhancer Factor 1 Beta Subunit
NCBI: 16q22.1    Ensembl: 16q22.1
PEBB_HUMANSize: 182 amino acidsMass: 21508 Da

  • Subunit: Heterodimer with RUNX1. Interacts with COPRS (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB (By similarity) 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for CBFB: 1CL3 (3D) [IMAGE] 1E50 (3D) [IMAGE] 1H9D (3D) [IMAGE] 4N9F (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: PEBB_HUMAN, Q13951 Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1
  • Similarity:
    Belongs to the CBF-beta family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR003417CBF_betaCore binding factor, beta subunitFamily
    BlocksIPB003417Core binding factorCore binding factor, beta subunit

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process transcription from RNA polymerase II promoter TAS GOA 8351518
    Cellular Component membrane IDA GOA 19946888
    Molecular Function protein binding IPI GOA 10856244
    sequence-specific DNA binding transcription factor activity TAS GOA 8351518

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11

    CBFB cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene