Gene content  |
| CCL2 ( by HUGO) |
| Chemokine (C-C Motif) Ligand |
| Other |
| Chemokine (C-C Motif) Ligand 2 SCYA2 Monocyte Chemotactic And Activating Factor Monocyte Chemotactic Protein 1 Monocyte Secretory Protein JE MCAF MCP1 Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1 Homologous To Mouse Sig-Je) Monocyte Chemoattractant Protein-1 Monocyte Chemoattractant Protein 1 Small-Inducible Cytokine A2 HC11 MCP-1 Homologous To Mouse Sig-Je Member 2 Small Inducible Cytokine Subfamily A (Cys-Cys) GDCF-2 HSMCR30 SMC-CF C-C Motif Chemokine 2 Small Inducible Cytokine Subfamily A (Cys-Cys) Member 2 |
| NCBI: 17q11.2-q12 Ensembl: 17q12 |
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Subunit: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for CCL2 (see all 10): 1DOK (3D) [IMAGE] 1DOL (3D) [IMAGE] 1DOM (3D) [IMAGE] 1DON (3D) [IMAGE] 1MCA (3D) [IMAGE] 1ML0 (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: CCL2_HUMAN, P13500 Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis
Similarity: Belongs to the intercrine beta (chemokine CC) family [IMAGE]
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