Gene content    
CCNA2 ( by HUGO)
Cyclin A2
Oncogene
Cyclin A2
CCN1
CCNA
cyclin-A
cyclin-A2
Cyclin-A
NCBI: 4q27    Ensembl: 4q27
CCNA2_HUMANSize: 432 amino acidsMass: 48551 Da

  • Subunit: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for CCNA2 (see all 81): 1E9H (3D) [IMAGE] 1FIN (3D) [IMAGE] 1FVV (3D) [IMAGE] 1GY3 (3D) [IMAGE] 1H1P (3D) [IMAGE] 1H1Q (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: CCNA2_HUMAN, P20248 Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions
  • Similarity:
    Belongs to the cyclin family. Cyclin AB subfamily [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR004367Cyclin_C-domCyclin, C-terminalDomain
    IPR006671Cyclin_NCyclin, N-terminalDomain
    BlocksIPB006670CyclinCyclin

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process mitotic G2 DNA damage checkpoint TAS GOA 1312467
    Ras protein signal transduction IEP GOA 9054499
    Cellular Component nucleus IDA GOA 16109376

    CCNA2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene