Gene content    
CCND2 ( by HUGO)
Cyclin D2
Oncogene
Cyclin D2
G1/S-Specific Cyclin D2
KIAK0002
G1/S-Specific Cyclin-D2
NCBI: 12p13    Ensembl: 12p13.32
CCND2_HUMANSize: 289 amino acidsMass: 33067 Da

  • Subunit: Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity
  • Function:
    UniProtKB/Swiss-Prot Summary: CCND2_HUMAN, P30279 Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity)
  • Similarity:
    Belongs to the cyclin family. Cyclin D subfamily
                          
    Contains 1 cyclin N-terminal domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR004367Cyclin_C-domCyclin, C-terminalDomain
    IPR006671Cyclin_NCyclin, N-terminalDomain
    BlocksIPB006670CyclinCyclin

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA GOA 8114739
    positive regulation of protein phosphorylation IDA GOA 8114739
    Cellular Component chromatin IDA GOA 18827403
    cyclin-dependent protein kinase holoenzyme complex IDA GOA 18827403
    cytosol IDA GOA 18827403
    nuclear membrane IDA GOA 18827403
    nucleolus IDA GOA 18827403
    Molecular Function protein binding IPI GOA 16189514
    protein kinase binding IPI GOA 8114739

    CCND2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene