Gene content
Symbol	CCNE1 ( by HUGO)
Name	Cyclin E1
Category	Oncogene
Alias	Cyclin E1 CCNE Cyclin Es Cyclin Et Cyclin E Variant Ex5del Cyclin E Variant Ex7del G1/S-Specific Cyclin-E1
Cytogenetic band	NCBI: 19q12    Ensembl: 19q12
Protein information	CCNE1_HUMAN Size: 410 amino acids Mass: 47077 Da Subunit: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for CCNE1: 1W98 (3D) [IMAGE] Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNE1 (see all 9): G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat Notch Signaling Function: UniProtKB/Swiss-Prot Summary: CCNE1_HUMAN, P24864 Function: Essential for the control of the cell cycle at the G1/S (start) transition Similarity: Belongs to the cyclin family. Cyclin E subfamily [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR004367	Cyclin_C-dom	Cyclin, C-terminal	Domain
	IPR006671	Cyclin_N	Cyclin, N-terminal	Domain
Blocks	IPB006670	Cyclin	Cyclin

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	androgen receptor signaling pathway	NAS	GOA	15572661
	G1/S transition of mitotic cell cycle	NAS	GOA	8207080
	positive regulation of transcription, DNA-templated	NAS	GOA	15572661
	protein phosphorylation	IMP	GOA	10500095
Molecular Function	androgen receptor binding	NAS	GOA	15572661
	protein binding	IPI	GOA	10330164
	transcription coactivator activity	NAS	GOA	15572661

CCNE1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene