Gene content    
CCNE2 ( by HUGO)
Cyclin E2
Other
Cyclin E2
CYCE2
G1/S-Specific Cyclin-E2
NCBI: 8q22.1    Ensembl: 8q22.1
CCNE2_HUMANSize: 404 amino acidsMass: 46757 Da

  • Subunit: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex
  • Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubM
  • Function:
    UniProtKB/Swiss-Prot Summary: CCNE2_HUMAN, O96020 Function: Essential for the control of the cell cycle at the late G1 and early S phase
  • Similarity:
    Belongs to the cyclin family. Cyclin E subfamily [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR004367Cyclin_C-domCyclin, C-terminalDomain
    IPR006671Cyclin_NCyclin, N-terminalDomain
    BlocksIPB006670CyclinCyclin

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell cycle checkpoint TAS GOA 9858585
    Molecular Function protein binding IPI GOA 15232106

    CCNE2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene