Gene content  |
| CDC2L1 (approved by HUGO) |
| cell division cycle 2-like 1 (PITSLRE proteins) |
| Tumor suppressor gene |
| EC 2.7.1.37CDK11CDK11-p110CDK11-p46CDK11-p58CLK-1PITSLREAPK58p58p58CDC2L1p58CLK-1 |
| NCBI: 1p36 Ensembl: 1p36.33 |
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Subcellular location: Cytoplasmic and nuclear
Subunit: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 and RANBP9. The cleaved p110 isoform interacts with RNPS1. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7
Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression
Catalytic activity: ATP + a protein = ADP + a phosphoprotein
Similarity: Belongs to the Ser/Thr protein kinase family. CDC2/CDKX subfamily
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