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Subunit: Homodimer. Interacts with DAPK3 (By similarity). Binds DNA. Binds to adeno-pre-mRNA in an ATP-stimulated manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts with CTNNBL1 Sequence caution: Sequence=BAA24862.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for CDC5L: 2DIM (3D) [IMAGE] 2DIN (3D) [IMAGE]
Tissue specificity: Ubiquitously expressed in both fetal and adult tissues [IMAGE] Custom PCR Arrays for CDC5L Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for CDC5L OriGene qSTAR qPCR primer pairs in human, mouse for CDC5L [IMAGE] Pre-validated
Function: UniProtKB/Swiss-Prot Summary: CDC5L_HUMAN, Q99459 Function: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing
Similarity: Belongs to the CEF1 family Contains 2 HTH myb-type DNA-binding domains [IMAGE]
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