Gene content    
CDH1 ( by HUGO)
Cadherin 1, Type 1, E-Cadherin (Epithelial)
Tumor suppressor gene
Cadherin 1
Type 1
E-Cadherin (Epithelial)
UVO
E-Cadherin
Epithelial Cadherin
CDHE
CAM 120/80
ECAD
LCAM
Arc-1
CD324
Cadherin 1
E-Cadherin (Epithelial)
cadherin-1
Calcium-Dependent Adhesion Protein
Epithelial
Cell-CAM 120/80
uvomorulin
E-cadherin
Uvomorulin
CD324 Antigen
NCBI: 16q22.1    Ensembl: 16q22.1
CADH1_HUMANSize: 882 amino acidsMass: 97456 Da

  • Subunit: Homodimer; disulfide-linked. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (By similarity). Interacts with TBC1D2. Interacts with LIMA1. Interacts with CAV1. Interacts with the TRPV4 and CTNNB1 complex (By similarity). Interacts with PIP5K1C. Interacts with RAB8B (By similarity). Interacts with RAPGEF2 (By similarity). Interacts with DDR1; this stabilizes CDH1 at the cell surface and inhibits its internalization Sequence caution: Sequence=AAA61259.1; Type=Frameshift; Positions=16, 22, 25, 28, 31, 34, 52, 67, 73, 76, 94, 102, 633, 636; Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for CDH1 (see all 12): 1O6S (3D) [IMAGE] 2O72 (3D) [IMAGE] 2OMT (3D) [IMAGE] 2OMU (3D) [IMAGE] 2OMV (3D) [IMAGE] 2OMX (3D) [IMAGE]
  • Tissue specificity: Non-neural epithelial tissues [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH1 (see all 17): Lung Cancer in human mouse rat Extracellular Matrix & Adhesion Molecules in human mouse rat Adherens Junctions in human mouse rat Wound He
  • Function:
    UniProtKB/Swiss-Prot Summary: CADH1_HUMAN, P12830 Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 Function: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production
  • Similarity:
    Contains 5 cadherin domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000233Cadherin_cytoplasmic-domCadherin cytoplasmic regionDomain
    IPR002126CadherinCadherinDomain
    BlocksIPB000233Cadherin cytoplasmic regionCadherin cytoplasmic region
    IPB002126CadherinCadherin

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cellular response to indole-3-methanol IDA GOA 10868478
    cellular response to lithium ion IDA GOA 12937339
    homophilic cell adhesion via plasma membrane adhesion molecules NAS GOA 16338932
    negative regulation of cell-cell adhesion IMP GOA 19653274
    positive regulation of transcription factor import into nucleus IDA GOA 16338932
    positive regulation of transcription, DNA-templated IDA GOA 16338932
    single organismal cell-cell adhesion IDA GOA 16338932
    Cellular Component actin cytoskeleton IDA GOA 16338932
    apical junction complex IDA GOA 10460003
    catenin complex IDA GOA 18593713
    cell junction IDA GOA 19038973
    cell junction TAS GOA 17047063
    cell-cell adherens junction IDA GOA 16338932
    integral component of membrane IDA GOA 16338932
    lateral plasma membrane IDA GOA 16338932
    perinuclear region of cytoplasm IDA GOA 16338932
    trans-Golgi network IMP GOA 17620337
    Molecular Function ankyrin binding IPI GOA 17620337
    beta-catenin binding IDA GOA 17620337
    cell adhesion molecule binding NAS GOA 16338932
    gamma-catenin binding IPI GOA 1639850
    protein binding IPI GOA 11401320

    Disorder & Mutation    
    Source Disease
    SWISS-PROTHereditary diffuse gastric cancer (HDGC) [MIM:137215]: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry. Heterozygous CDH1 germline mutations are responsible for familial cases of diffuse gastric cancer. Somatic mutations has also been found in patients with sporadic diffuse gastric cancer and lobular breast cancer
    SWISS-PROTEndometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry
    SWISS-PROTOvarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

    CDH1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene