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Subunit: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape (By similarity) Developmental stage: Expressed at higher levels in adult brain than in developing brain 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for CDH13: 2V37 (3D) [IMAGE]
Tissue specificity: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH
Function: UniProtKB/Swiss-Prot Summary: CAD13_HUMAN, P55290 Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth
Similarity: Contains 5 cadherin domains [IMAGE]
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