Gene content  |
| CDKN2B ( by HUGO) |
| Cyclin-Dependent Kinase Inhibitor |
| Tumor suppressor gene |
| Cyclin-Dependent Kinase Inhibitor 2B (P15 Inhibits CDK4) MTS2 Multiple Tumor Suppressor 2 MTS-2 p14-INK4b p15-INK4b INK4B P15 CDK4I TP15 CDK Inhibitory Protein CDK4B Inhibitor Cyclin-Dependent Kinase 4 Inhibitor B Cyclin-Dependent Kinases 4 And 6 Binding Protein p14_INK4B P14_CDK Inhibitor P15 CDK Inhibitor p15INK4b p15_INK4B p15INK4B |
| NCBI: 9p21 Ensembl: 9p21.3 |
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Subunit: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6
Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2B (see all 9): Oncogenes & Tumor Suppressor Genes in human mouse rat Lung Cancer in human mouse rat
Function: UniProtKB/Swiss-Prot Summary: CDN2B_HUMAN, P42772 Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest
Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family Contains 4 ANK repeats [IMAGE]
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