Gene content    
CDKN2C ( by HUGO)
Cyclin-Dependent Kinase Inhibitor
Tumor suppressor gene
Cyclin-Dependent Kinase Inhibitor 2C (P18
Inhibits CDK4)
p18-INK6
INK4C
CDK6 Inhibitor P18
Cyclin-Dependent Inhibitor
Cyclin-Dependent Kinase 4 Inhibitor C
Cyclin-Dependent Kinase 6 Inhibitor P18
p18
p18-INK4C
CDKN6
Cyclin-Dependent Kinase 6 Inhibitor
p18-INK4c
NCBI: 1p32    Ensembl: 1p32.3
CDN2C_HUMANSize: 168 amino acidsMass: 18127 Da

  • Subunit: Heterodimer of p18 with CDK6 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for CDKN2C: 1BU9 (3D) [IMAGE] 1G3N (3D) [IMAGE] 1IHB (3D) [IMAGE] 1MX2 (3D) [IMAGE] 1MX4 (3D) [IMAGE] 1MX6 (3D) [IMAGE]
  • Tissue specificity: Highest levels found in skeletal muscle. Also found in pancreas and heart [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2C: Polycomb & Trithorax Target Genes in human mouse rat Lymphoma in human mouse rat Cellular Senescence in h
  • Function:
    UniProtKB/Swiss-Prot Summary: CDN2C_HUMAN, P42773 Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB
  • Similarity:
    Belongs to the CDKN2 cyclin-dependent kinase inhibitor family
                          
    Contains 4 ANK repeats [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002110Ankyrin_rptAnkyrinRepeat
    BlocksIPB002110Ankyrin repeat signatureAnkyrin repeat signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell cycle arrest IDA GOA 10208428
    G1/S transition of mitotic cell cycle IDA GOA 10208428
    negative regulation of cell growth IDA GOA 10208428
    negative regulation of cell proliferation IDA GOA 10208428
    negative regulation of phosphorylation IDA GOA 10208428
    negative regulation of protein serine/threonine kinase activity IDA GOA 8001816
    regulation of cyclin-dependent protein serine/threonine kinase activity IDA GOA 8001816
    Cellular Component cytoplasm IDA GOA 11800646
    nucleus IDA GOA 11800646
    Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity IDA GOA 8001816
    protein binding IPI GOA 18394558
    protein kinase binding IPI GOA 8001816

    CDKN2C cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene