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Subunit: Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding. Interacts with MVB12A, VPS37B, VPS37C and VPS28 Sequence caution: Sequence=BAA91670.1; Type=Erroneous initiation; Note=Translation N-terminally extended; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for CEP55: 3E1R (3D) [IMAGE]
Tissue specificity: Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta
Function: UniProtKB/Swiss-Prot Summary: CEP55_HUMAN, Q53EZ4 Function: Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis Gene Ontology (GO): 1 molecular function term: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 16189514 [IMAGE] Find genes that share ontologies with CEP55 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for CEP55: Increased cell number in G1, s Increased gamma-H2AX phosphory Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEP55 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEP55 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEP55 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEP55 miRNA Products: miRTarBase miRNAs that target CEP55: hsa-mir-1229-3p (MIRT036269), hsa-mir-192-5p (MIRT026277), hsa-mir-215-5p (MIRT024828), hsa-mir-27a-3p (MIRT050017), hsa-mir-155-5p (MIRT020611), hsa-mir-103a-3p (MIRT026998), hsa-mir-16-5p (MIRT031510) [IMAGE] Block miRNA regulation of human, mouse, rat CEP55 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate CEP55 (see all 13): hsa-miR-3163 hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-144 hsa-miR-19b hsa-miR-454 hsa-miR-4295 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: CEP55 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for CEP55 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat CEP55 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for CEP55 Clone Products: [IMAGE] OriGene clones in human, mouse for CEP55 (see all 12) OriGene ORF clones in mouse, rat for CEP55 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 2): CEP55 (NM_018131) [IMAGE] Sino Biological Human cDNA Clone for CEP55 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP55 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP55 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for CEP55 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for CEP55 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP55
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