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Subunit: Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated) Sequence caution: Sequence=BAB55248.1; Type=Frameshift; Positions=597;
Tissue specificity: Frequently overexpressed in hepatomacellular carcinomas [IMAGE] Custom PCR Arrays for CHD1L Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for CHD1L [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHD1L [IMAGE] Q
Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding
Catalytic activity: ATP + H(2)O = ADP + phosphate Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121 Gene Ontology (GO): Selected molecular function terms (see all 10): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding IDA 19661379 GO:0003676 nucleic acid binding -- -- GO:0003677 DNA binding IEA -- GO:0004003 ATP-dependent DNA helicase activity TAS 19661379 GO:0004386 helicase activity -- -- [IMAGE] Find genes that share ontologies with CHD1L About GenesLikeMe Phenotypes: 1 MGI phenotypic allele [IMAGE] for Chd1l (no phenotypes) [IMAGE] Find genes that share phenotypes with CHD1L About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHD1L [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHD1L [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHD1L [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHD1L miRNA Products: miRTarBase miRNAs that target CHD1L: hsa-mir-320a (MIRT044802) [IMAGE] Block miRNA regulation of human, mouse, rat CHD1L using miScript Target Protectors [IMAGE] Search for qRT-PCR Assays for microRNAs that regulate CHD1L [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: CHD1L 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for CHD1L [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat CHD1L Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for CHD1L Clone Products: [IMAGE] OriGene clones in human, mouse for CHD1L (see all 7) OriGene ORF clones in mouse, rat for CHD1L OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: CHD1L (NM_004284) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHD1L [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1L Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for CHD1L [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for CHD1L [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1L
Similarity: Belongs to the SNF2/RAD54 helicase family Contains 1 helicase ATP-binding domain Contains 1 helicase C-terminal domain Contains 1 Macro domain [IMAGE]
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