Gene content    
CHRM3 ( by HUGO)
Cholinergic Receptor, Muscarinic 3
Other
Cholinergic Receptor
Muscarinic 3
EGBRS
Acetylcholine Receptor
Muscarinic 3
HM3
Acetylcholine Receptor
Muscarinic 3
M3 Muscarinic Receptor
Muscarinic Acetylcholine Receptor M3
NCBI: 1q43    Ensembl: 1q43
ACM3_HUMANSize: 590 amino acidsMass: 66128 Da

  • Function:
    UniProtKB/Swiss-Prot Summary: ACM3_HUMAN, P20309 Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
  • Similarity:
    Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamilyFamily
    IPR000995Musac_Ach_rcptMuscarinic acetylcholine receptorFamily
    IPR001183Musac_Ach_M3_rcptMuscarinic acetylcholine receptor M3Family
    BlocksIPB000995Muscarinic acetylcholine receptor signatureMuscarinic acetylcholine receptor signature
    IPB001183Muscarinic M3 receptor signatureMuscarinic M3 receptor signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell proliferation TAS GOA 8063729
    cellular protein modification process TAS GOA 10051746
    G-protein coupled receptor signaling pathway TAS GOA 9603968
    nervous system development TAS GOA 2739737
    signal transduction TAS GOA 10940357
    Molecular Function phosphatidylinositol phospholipase C activity TAS GOA 1905013
    protein binding IPI GOA 19575010
    receptor activity TAS GOA 10940357

    Disorder & Mutation    
    Source Disease
    SWISS-PROTEagle-Barrett syndrome (EGBRS) [MIM:100100]: A syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry

    CHRM3 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene