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Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. Interacts with BRSK2 Miscellaneous: The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex Sequence caution: Sequence=AAL82571.1; Type=Erroneous initiation; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for COPS5: 4F7O (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: CSN5_HUMAN, Q92905 Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2 Enzyme Number (IUBMB): EC 3.4.-.-1 Gene Ontology (GO): Selected molecular function terms (see all 6): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003713 transcription coactivator activity TAS 8837781 GO:0003743 translation initiation factor activity TAS 9341143 GO:0004843 ubiquitin-specific protease activity IDA 19246649 GO:0005515 protein binding IPI 12082530 GO:0008237 metallopeptidase activity IMP 19214193 [IMAGE] Find genes that share ontologies with COPS5 About GenesLikeMe Phenotypes: 3 GenomeRNAi human phenotypes for COPS5: Increased cell death in HCT116 Increased gamma-H2AX phosphory Synthetic lethal with Ras
Similarity: Belongs to the peptidase M67A family. CSN5 subfamily Contains 1 MPN (JAB/Mov34) domain [IMAGE]
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