Gene content    
CRKL ( by HUGO)
V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like
Oncogene
V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like
Crk-Like Protein
NCBI: 22q11.21    Ensembl: 22q11.21
CRKL_HUMANSize: 303 amino acidsMass: 33777 Da

  • Subunit: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for CRKL: 2BZX (3D) [IMAGE] 2BZY (3D) [IMAGE] 2DBK (3D) [IMAGE] 2EO3 (3D) [IMAGE] 2LQN (3D) [IMAGE] 2LQW (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: CRKL_HUMAN, P46109 Function: May mediate the transduction of intracellular signals
  • Similarity:
    Belongs to the CRK family
                          
    Contains 1 SH2 domain
                          
    Contains 2 SH3 domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000980SH2SH2 motifDomain
    IPR001452SH3_domainSH3Domain
    IPR011511SH3_2Variant SH3Domain
    BlocksIPB000980SH2 domain signatureSH2 domain signature
    IPB001452SH3 domain signatureSH3 domain signature
    IPB011511Variant SH3Variant SH3

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process intracellular signal transduction TAS GOA 8361759
    JNK cascade TAS GOA 8798523
    positive regulation of signal transduction TAS GOA 8798523
    Ras protein signal transduction TAS GOA 8798523
    Molecular Function protein binding IPI GOA 16273093
    SH3/SH2 adaptor activity TAS GOA 8798523
    signal transducer activity TAS GOA 8361759

    CRKL cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene