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Subunit: Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1
Tissue specificity: Highly expressed in proliferating cells [IMAGE] Custom PCR Arrays for CSE1L Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for CSE1L [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSE1L [IMAGE] QuantiTect SYBR G
Function: UniProtKB/Swiss-Prot Summary: XPO2_HUMAN, P55060 Function: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Similarity: Belongs to the XPO2/CSE1 family Contains 1 importin N-terminal domain [IMAGE]
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