|
Subunit: Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16 Miscellaneous: Valuable marker for several incompletely differentiated precursor cells
Tissue specificity: Detected only in malignant melanoma cells [IMAGE] Custom PCR Arrays for CSPG4 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for CSPG4 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSPG4 [IMAGE] QuantiTect SYBR
Function: UniProtKB/Swiss-Prot Summary: CSPG4_HUMAN, Q6UVK1 Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades Enzyme Numbers (IUBMB): EC 3.6.32 EC 2.7.82 Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004871 signal transducer activity IEA -- GO:0005515 protein binding -- -- GO:0019901 protein kinase binding IPI 10587647 [IMAGE] Find genes that share ontologies with CSPG4 About GenesLikeMe Phenotypes:
Similarity: Contains 15 CSPG (NG2) repeats Contains 2 laminin G-like domains [IMAGE]
|
