Gene content    
CTBP1 ( by HUGO)
C-Terminal Binding Protein 1
Tumor suppressor gene
C-Terminal Binding Protein 1
Brefeldin A-Ribosylated Substrate
BARS
C-Terminal-Binding Protein 1
CTBP
CtBP1
EC 1.1.1.-
EC 1.1.1
EC 1.1.1.158
NCBI: 4p16    Ensembl: 4p16.3
CTBP1_HUMANSize: 440 amino acidsMass: 47535 Da

  • Subunit: Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Interacts with BCL6; the interaction is required for BCL6 transcriptional autoinhibition and inhibition of some BCL6 target genes 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for CTBP1: 1MX3 (3D) [IMAGE]
  • Tissue specificity: Expressed in germinal center B-cells [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CTBP1: WNT Signaling Pathway in human mouse rat Polycomb & Trithorax Complexes in human mouse rat Tumor Metastasis in human mouse rat Epigenetic Chrom
  • Function:
    UniProtKB/Swiss-Prot Summary: CTBP1_HUMAN, Q13363 Function: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation
  • Similarity:
    Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR006139D-isomer_2_OHA_DH_cat_domD-isomer specific 2-hydroxyacid dehydrogenase, catalytic regionDomain
    IPR006140D-isomer_2_OHA_DH_NAD-bdD-isomer specific 2-hydroxyacid dehydrogenase, NAD-bindingDomain
    BlocksIPB006139D-isomer specific 2-hydroxyacid dehydrogenaseD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of cell proliferation TAS GOA 7479821
    negative regulation of transcription from RNA polymerase II promoter IMP GOA 19162039
    protein phosphorylation TAS GOA 8440238
    viral genome replication TAS GOA 7479821
    Cellular Component transcriptional repressor complex IDA GOA 16287852
    Molecular Function protein binding IPI GOA 11568182
    protein C-terminus binding TAS GOA 8440238
    protein domain specific binding IDA GOA 19162039
    protein domain specific binding IPI GOA 18374649
    repressing transcription factor binding IPI GOA 19162039
    transcription factor binding IPI GOA 16609867

    CTBP1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene