TAG for CTBP2

Gene content

Symbol

CTBP2 (-- by HUGO)

Name

C-terminal binding protein 2 CTBP2: Approved

Category

-- & Tumor suppressor gene

Alias

C-terminal
binding
protein
11
ribeye
C-terminal-binding
protein

Cytogenetic band

NCBI: 10q26.13 Ensembl: 10q26.13

Protein information

CTBP2_HUMAN

Size: 445 amino acids

Mass: 48945 Da

Subcellular location: Nucleus (Potential). Cell junction, synapse (By similarity) PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] : 2OME (3D) [IMAGE] Secondary accessions: A8K2X5 D3DRF5 O43449 Q5SQP7 Q69YI3 Q86SV0 Q9H2T8 Alternative splicing: 2 isoforms: P56545-1 P56545

Subunit: Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ

Tissue specificity: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas

Similarity:

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR006139	D-isomer_2_OHA_DH_cat_dom	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region	Domain
InterPro	IPR006140	D-isomer_2_OHA_DH_NAD-bd	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	Domain
Blocks	IPB006139	D-isomer specific 2-hydroxyacid dehydrogenase	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	metabolism	IEA	GOA
	NAD binding	IEA	GOA
	negative regulation of cell proliferation	TAS	GOA	PubMed
	nucleus	IEA	GOA
	oxidoreductase activity	IEA	GOA
	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	GOA
Molecular Function	L-serine biosynthesis	IEA	GOA
Molecular Function	viral genome replication	TAS	GOA	PubMed

CTBP2 cross reference