Gene content  |
| CTDSP2 ( by HUGO) |
| CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide... |
| Other |
| CTD (Carboxy-Terminal Domain RNA Polymerase II Polypeptide A) Small Phosphatase 2 NLI-Interacting Factor 2 Nuclear LIM Interactor-Interacting Factor 2 Small CTD Phosphatase 2 Conserved Gene Amplified In Osteosarcoma Protein OS-4 Small C-Terminal Domain Phosphatase 2 OS4 SCP2 EC 3.1.3.16 PSR2 Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2 NIF2 |
| NCBI: 12q14.1 Ensembl: 12q14.1 |
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Subunit: Monomer (By similarity). Interacts with REST Sequence caution: Sequence=AAB71816.1; Type=Frameshift; Positions=267; Sequence=AAP34399.1; Type=Frameshift; Positions=267; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for CTDSP2: 2Q5E (3D) [IMAGE]
Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver [IMAGE] Custom PCR Arrays for CTDSP2 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for CTDSP2 OriGene qSTAR qPCR primer pairs
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Similarity: Contains 1 FCP1 homology domain [IMAGE]
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