Gene content
Symbol	CTGF ( by HUGO)
Name	Connective Tissue Growth Factor
Category	Oncogene
Alias	Connective Tissue Growth Factor Hypertrophic Chondrocyte-Specific Protein 24 Insulin-Like Growth Factor-Binding Protein 8 CCN2 HCS24 IBP-8 IGFBP-8 IGFBP8 CCN Family Member 2 IGF-Binding Protein 8 NOV2
Cytogenetic band	NCBI: 6q23.1    Ensembl: 6q23.2
Protein information	CTGF_HUMAN Size: 349 amino acids Mass: 38091 Da Subunit: Monomer Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CTGF (see all 11): G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat Fibrosis Function: UniProtKB/Swiss-Prot Summary: CTGF_HUMAN, P29279 Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis Similarity: Belongs to the CCN family                        Contains 1 CTCK (C-terminal cystine knot-like) domain                        Contains 1 IGFBP N-terminal domain                        Contains 1 TSP type-1 domain                        Contains 1 VWFC domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000867	IGFBP-like	Insulin-like growth factor-binding protein, IGFBP	Domain
	IPR000884	Thrombospondin_1_rpt	Thrombospondin, type I	Repeat
	IPR001007	VWF_C	von Willebrand factor, type C	Domain
	IPR006207	Cys_knot_C	Cystine knot, C-terminal	Domain
	IPR006208	Cys_knot	Cystine knot	Domain
	IPR009030	Growth_fac_rcpt_N_dom	Growth factor, receptor	Domain
	IPR012395	IGFBP_CNN	IGFBP-related, CNN	Family
Blocks	IPB000867	Insulin-like growth factor-binding protein	Insulin-like growth factor-binding protein, IGFBP
	IPB000884	Thrombospondin	Thrombospondin, type I
	IPB001007	von Willebrand factor	von Willebrand factor, type C
	IPB006207	Cystine knot	Cystine knot, C-terminal
	IPB006208	Cystine knot domain	Cystine knot domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	epidermis development	TAS	GOA	10809757
	response to wounding	TAS	GOA	10809757
Cellular Component	plasma membrane	TAS	GOA	10809757
Molecular Function	protein binding	IPI	GOA	16457822

CTGF cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene