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Subunit: Part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone. Interacts with CUL9. Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or TP53. Interacts with TP53; the interaction preferentially involves tetrameric and dimeric TP53. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Interacts with CUL1; the interactions seems to be mediated by FBXW8 (By similarity). Interacts with SV40 Large T antigen; this interaction seems to inhibit CUL7. Component of a SCF-like complex composed of SV40 Large T antigen, CUL7, SKP1, RBX1, and FBXW8. Interacts with OBSL1 Sequence caution: Sequence=BAA07551.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for CUL7: 2JNG (3D) [IMAGE]
Tissue specificity: Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts [IMAGE] Pathway & Di
Function: UniProtKB/Swiss-Prot Summary: CUL7_HUMAN, Q14999 Function: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. In complex with FBXW8, mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005488 binding -- -- GO:0005515 protein binding IPI 17298945 GO:0031625 ubiquitin protein ligase binding IEA -- [IMAGE] Find genes that share ontologies with CUL7 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for CUL7: Increased cell death HMECs cel Increased gamma-H2AX phosphory
Similarity: Belongs to the cullin family Contains 1 DOC domain [IMAGE]
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