Gene content    
CXCL1 ( by HUGO)
Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating...
Oncogene
Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity
Alpha)
GRO1
MGSA
FSP
Fibroblast Secretory Protein
GRO1 Oncogene (Melanoma Growth Stimulating Activity
Alpha)
Neutrophil-Activating Protein 3
GRO-alpha(1-73)
NAP-3
SCYB1
C-X-C Motif Chemokine 1
GROa
MGSA-a
GRO1 Oncogene (Melanoma Growth-Stimulating Activity)
Growth-Regulated Alpha Protein
Melanoma Growth Stimulatory Activity Alpha
MGSA Alpha
GRO
GROA
Melanoma Growth Stimulatory Activity
NCBI: 4q21    Ensembl: 4q13.3
GROA_HUMANSize: 107 amino acidsMass: 11301 Da

  • Function:
    UniProtKB/Swiss-Prot Summary: GROA_HUMAN, P09341 Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding TAS 10820279 GO:0008009 chemokine activity IEA -- GO:0008047 enzyme activator activity TAS 9079638 GO:0008083 growth factor activity IEA -- [IMAGE] Find genes that share ontologies with CXCL1 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for CXCL1: Decreased focal adhesion (FA) Metaphase cells
  • Similarity:
    Belongs to the intercrine alpha (chemokine CxC) family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001089Chemokine_CXCSmall chemokine, C-X-CFamily
    IPR001811Chemokine_IL8-like_domSmall chemokine, interleukin-8-likeFamily
    BlocksIPB002473Interleukin-8 signatureInterleukin-8 signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process actin cytoskeleton organization TAS GOA 9725262
    cell chemotaxis TAS GOA 10820279
    cell proliferation TAS GOA 8380167
    chemotaxis TAS GOA 10820279
    G-protein coupled receptor signaling pathway TAS GOA 10820279
    intracellular signal transduction TAS GOA 9551928
    negative regulation of cell proliferation TAS GOA 9551928
    nervous system development TAS GOA 9058825
    positive regulation of catalytic activity TAS GOA 9079638
    signal transduction TAS GOA 10820279
    Molecular Function enzyme activator activity TAS GOA 9079638
    receptor binding TAS GOA 10820279

    CXCL1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene