Gene content    
CYP1A1 ( by HUGO)
Cytochrome P450, Family 1, Subfamily A, Polypeptide 1
Other
Cytochrome P450
Family 1
Subfamily A
Polypeptide 1
CYP1
Cytochrome P450
Subfamily I (Aromatic Compound-Inducible)
Polypeptide 1
Cytochrome P450 Form 6
Cytochrome P450-C
Cytochrome P450-P1
CYPIA1
EC 1.14.14.1
AHH
AHRR
CP11
P1-450
P450-C
P450DX
Aryl Hydrocarbon Hydroxylase
Cytochrome P1-450
Dioxin-Inducible
Cytochrome P450 1A1
Flavoprotein-Linked Monooxygenase
Xenobiotic Monooxygenase
NCBI: 15q24.1    Ensembl: 15q24.1
CP1A1_HUMANSize: 512 amino acidsMass: 58165 Da

  • Tissue specificity: Lung, lymphocytes and placenta [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP1A1 (see all 6): Estrogen Receptor Signaling in human mouse rat Cancer Drug Resistance in human mouse rat Drug Metabolism: Phase I Enzymes in human mouse
  • Function:
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
                          
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
  • Catalytic activity:
    RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
  • Similarity:
    Belongs to the cytochrome P450 family [IMAGE]
  • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001128Cyt_P450Cytochrome P450Family
    IPR002401Cyt_P450_E_grp-IE-class P450, group IFamily
    IPR008066Cyt_P450_E_grp-I_CYP1E-class P450, CYP IAFamily
    BlocksIPB002401E-class P450 group I signatureE-class P450 group I signature
    IPB008066CYP1A P450 family signatureCYP1A P450 family signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process drug metabolic process IDA GOA 19219744
    oxidation-reduction process IDA GOA 19219744
    vitamin D metabolic process IC GOA 15546903
    Molecular Function oxidoreductase activity IDA GOA 19219744
    oxygen binding TAS GOA 1691986
    vitamin D 24-hydroxylase activity IDA GOA 15546903

    CYP1A1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene